Keywords American: brain
damage, brain atrophy, brain atrophy reversed, brain shrinkage, neurogenesis, neuroplasticity,
neural progenitor cell, neural stem cell, cortex, large ventricles, ventriculomegaly, osteopath, fascia, SOT, cavitations,
NICO, osteonecrosis, root canals, root canal coverup, cadavers of the body, silver (mercury) fillings,
mercury toxicity, depression, bipolar disorder, lithium, neuroAIDS,
Alzheimer's, optics, optical prism, MRI, MRS, brain scan, susan sawicki
Keywords European: (Deu) kadaver des korpers, optik, optisches prisma, (Fr) systeme optique, prisme optique, (It) ottica, prisma ottico
NEUROGENESIS REPORT
by Susan Sawicki
{Updated March
2007}
We may be in the midst
of a revolution in our conception of the plasticity of the adult mammalian
brain.
(Quoting Charles
Gross of Princeton U., Yr 2000)
Does the adult human brain produce new
neurons to incorporate into the cerebral cortex, that outermost furrowed layer
of brain that we call upon for identity?
Neurogenesis is one of the hottest
controversies in American neuroscience, states a university student in a
research hub within the U.S. Where
better to turn for a settlement on the issue, than an NIH
budget proposal year 2007 to Congress?
One segment of the NIH, the NINDS, or National Institute of Neurological Disorders
& Stroke is nation’s leading supporter of research on the brain and nervous
system, and each year they must go before Congress to be funded:
Fiscal year 2007 Congressional Justification (2/07/06) for the NINDS:
[It is found] that the brains
of even adult mammals, including humans,
can generate new nerve cells to a limited degree. New research shows
that under appropriate circumstances the brains of adult mice can
replace
corticospinal neurons. These anatomically elaborate nerve cells
control
voluntary movement via very long nerve fibers that extend from the brain
to the spinal cord.
Id. at “Science Advances” at p. 8. (Emph.
added)
(www.ninds.nih.gov/news_and_events/congressional_testimony/index.htm
)
Here
Congress is told something indisputable, that adult human brains
generate new neurons in parts of the limbic system, ie.
at the olfactory bulb and at the hippocampus including
the dentate gyrus, an area linked to spatial
learning, memory and emotion. Who knew
what, and when, varies according to source 1/, 2/ but we can at least trace a stage of inquiry to
turn of the 20th Century – Gray’s Anatomy 1918 Ed. notes presence of pleomorphic (changing form) cells in the dentate gyrus. 3/ Recent
advances in laboratory detection have confirmed the growth of same new neurons,
a watershed event having taken place at the Salk Institute in San Diego (F.
Gage, PhD) in 1998. New neurons were
extracted from adult cadaverous dentate giri.4/
It wasn’t much, a few paltry new neurons in a reflexive part of
the brain. But from this point in time
1998, things happened faster.
What happened next? The answer, depends
upon where you look. Our newspapers
picked up the story of neurogenesis then dropped
it. The story stuck with us, that our
brains might be renewable. But how? 5/
Neuroscience went hard to work in the lab, fueled by large
funding to discover the neural stem cell--this was the hope of the paralyzed
Christopher Reeve. More quietly in the
lab, the midnight oil burns for one purpose; to make new grey matter, to
restore a human cortex to functionality.
The medical journals are a thick record of their trials, tribulations
and successes through the turn of this 21st Century. But little news. This century opens upon the Decade of the
Brain as labeled by the NINDS, and expectations are
increased in these years.
Expectations should now turn, to
in vivo whole brain restorations like the Sawicki
one, which was in itself unexpected. See
brain ( MRIs [Sawicki] before/after PAPIMI ), ( More MRIs . . . ) as imaged with MRI
before/after electromagnetic treatment with the PAPIMI
device. See case of brain restored and
tumor gone, also on this PAPIMI website as imaged
with CT-scan before/after treatment. ( http://www.papimi.gr/brain_catscan1-1.htm
), ( http://www.papimi.gr/brain_catscan2-1.htm
). Brain restoration with PAPIMI level of electromagnetic technology may or may not
be so surprising. But a brain increased
in size by taking lithium? This is
totally unexpected. You can see a brain
growing bigger on lithium on MRS (sister technology
to MRI -- 'S' for spectroscopy) brain scan at webpage
( http://www.psycheducation.org/mechanism/11Reversible.htm
) on Dr. Phelps' extraordinary
website Psycheducation.org., and pictures are from the NIMH. Here's the journal reference, 6/ and another. 7/ Some mood disorders involve brain
shrinkage as MRI/MRS informs us. These disorders were being cured by neurogenesis all the while and we didn't know it, and
according to recent information lithium is a causitive
agent to that end. Neurogenesis,
it might follow, is a virtual panacaea for many
things from depression to neuroAIDS, and it behooves
the interested reader to dig, and dig into the neuropsychiatric
and other literature for the whole story or it remains hidden. Your doctor may not have heard the news on
lithium.
Back to the Sawicki brain restoration, the PAPIMI
electromagnetic device and now also to it's inventor,
Dr. Panos Pappas.
Where is the inventor and his invention? Dr. Pappas is in Greece, and PAPIMI is used around the world to treat people's various
maladies. He is in a short line of
inventors holding patents for employing extremely brief and high powered
electric pulses in a classic electromagnetic therapy device, these pulses
adapted from WWII radar to new and "nonobvious"
use of probing the living cell wall to deliver healing energy. His patent is worldwide, 8/ and with it he
stands alone in his field for his disclosure, how to modify the pulse generator
to effect specified metabolic activity within the cell, based upon his unique
understanding of cellular metabolism.
How does his work impact the field?
It's too early to tell. Yet
several inventors soon after him, modify their pulse
generators in the same way he does, as the patent record shows. He defends successfully publicly, his unique
and in some respects controversial findings on cellular metabolism, as witness
the front section of his website. PAPIMI is not licensed for medical use in the U.S. and this
is where the story gets more interesting.
The U.S. Air Force now funds large, an extension of the same technology
to probe the living cell using short, high powered pulses adapted from WWII
radar and from, they go on to state, the atomic bomb and MRI
imager. 9/ In
contrast to Dr. Pappas' near-to-microsecond pulses 10-4 or <10-6,
their pulses are much shorter in nanoseconds 10-10 to probe the
cell's nuclear wall and allow for delivery of genetic work. Thus is born the new field of Bioelectrics.
They boast of curing cancer in mice--zapping tumors and making them
disappear. But they state the technology
is not yet proven safe or effective for use on people. This leads us back to the PAPIMI
and where to look for it, and unfortunately it's very, very scarcely found in
the U.S. PAPIMI
is in the class of older commercially available electromagnetic therapy devices
and as such, it submits to FDA rigours which forbid
one to say a cancer has been cured. PAPIMI is stalled in Phase 2 trials with the fairly recent
passing of U.S. coordinator Chuck Wallach. This author was very lucky to take part in an
informal Phase 1 in 1996 to treat [my] brain.
No formal study was built upon those results, because main medicine
wasn't interested. Today the only U.S.
citizens with unfettered access to the PAPIMI are our
soldiers on the battlefield because it's among the Military's pick of
"easily administered and portable treatments." 10/ Brain atrophy reversal is our subject,
isn't it? Well, here's a device that
reverses brain atrophy, possibly cures cancer (by reference to Air Force
claims), is easily administered, is low cost per treatment, and portable. And you U.S. citizens, you Americans,
can't put your hands on it? It's time
for a Revolution. And we'll do it the
American way, with sex and celebrity so now, it's time to make brain atrophy
sexy and famous so that we gain access to medical treatment for a condition
that goes untreated. What is the first
thing which may draw the public's attention to us? An increasing incidence of brain atrophy in
people of successively younger ages, and no answers or treatment offered.
Back
in the neuroscience laboratory in this January 2007, brain researchers haven’t
yet identified the neural stem cell, that stem cell which “by strict
definition” (F. Gage) generates almost any variety of cell needed by the brain
and is self-renewing. 11/ Known stem
cells, ex. embryonic or adult blood, when harvested have a very long and stable
shelf life and, on cue multiply to the nth power and transform into any mature
cell needed, and then renew. Thus
neuroscience is deprived of organ transplant, assayed drug
development, and new testing standards.
Use of the Genome project is held back for brain researchers. A difficulty is, no stem cell gives rise directly
to a neuron but instead gives rise to an intermediary form, a progenitor
cell. So what? There's more.
Scientists culture tiny globs of fetal neurological tissue (neurospheres) which contain the stem cells widely accepted
to give rise to neurons. These stem
cells are sensitive to the chemical medium used, and will multiply there but
won't change much. Then the medium has
to be changed out and that's when these particular cells go their own way. "After [medium] withdrawal, the
overwhelming
majority of these cells were unable to undergo neuronal differentiation
directly. However, if they were allowed
to undergo cell division while migrating from the neurosphere
in the absence of [medium], then neurogenesis could
proceed through the generation of neuronal progenitors." 12/ Comedy is hard, dying is easy.
So now we are nearer the
answer, whether the adult human brain produces new neurons to incorporate into
the cerebral cortex--and the answer is yes.
It occurs among us now in very ordinary, and in extraordinary ways and
it is showing up on our MRI & MRS
films. How much, and what's the extent
of this neurogenesis?
It's greater than you can ever imagine, and I'll walk you into it. "We may be in the midst of a revolution
in our conception of the plasticity of the adult mammalian brain." (Ibid.) This twice quoted observation is acute. We as people, must
conceive of our brains as renewable to know of, and take advantage of the
existing means and possibilities for renewal. Scientists must conceive of our brains as
renewable or "neuroplastic" if they are to
drive the engine of discovery forward. I
report to you the revolution has begun: "Dr. Gelbard
mentions . . . a reversal of the understanding that neurological disease, once
it began, was a 'one-way sort of ticket. You weren't going to get better. You
were just going to keep losing faculties. Well, that wasn't the case. [Para.] Researchers have realized that neurologic
disease has a reversible component, though ultimately not wholly reversible."
This is in reference to neuroAIDS and it is quoted from an AIDS community-based
magazine, A&U Nov. 2006
Issue 145 at p. 34 (Albany, NY).
Here's the story Field of
Diamonds, about the man who left his home and land to go mine diamonds in
the mountains, only to return empty handed and discover his former homeland
overrun with successful diamond mines.
You've heard this homily about looking first in your own back yard for,
well, diamonds but I pose a technical argument for you to look up several of
the Moh's scale gems ie. diamonds, rubies and then calcite, prefereably
on the internet and enjoy yourself.
Why? Because brilliant
neurogenesis is at hand, and it's more than diamonds. When you enter a jewelry store everything is
new, unique and brilliant; 1m points of shifting light spread out finely in
layers and in molting colors, as sensuous as polished lips. The first impression is the lasting one. If you go into a gem shop where the stones
are cut, you see more. Opening a jewelry
box, is a compounding of permanent memories. Read on, and I'll direct you to crystalline
caves. Segway;
new findings that bone marrow stem cells, and hair follicle bulge stem cells
each can, and do become neurons on their own.
Stem cells are diamonds and, much like the diamond, the neural stem cell
itself, eludes investigators, but its progeny, the "dormant"
progenitor cell which lays dormant in our grey matter, made history the summer
of 2006 when, on cue and with the close aid of scientists, it produced many,
many neurons. "Theoretically one
progenitor cell can be coaxed into producing neurons enough to make 50 million
brains, or 1016." 13/ This isn't a hoax, it's from McKnight
Brain Institute, U. Fla. 2006 and funded by the NINDS. The news which gets wider press,
is the progenitor cell is an ordinary brain cell: it's of the tissue which
provides neurons of the grey matter their structural support, nourishment and
drainage. The progenitor, like sapphires
and rubies do industrial work and are lasting, and as to beauty, like the
sapphire, its beauty and variety will be made to shine as scientists learn to uncrust it from its sediment. But back to the brain; making a mountain of
new brain matter is of limited use, unless it can then be grafted into the
living brain and there reestablish [injured] neuronal networks to
functionality. Next come the lab mice
and with them, the bearing of good news:
"It was a long and difficult process, but we were able to induce
what are basically support
cells in the
human brain to form beautiful new neurons in a dish," said Noah Walton [at
McKnight Brain
Institute]. "But what we really
needed is for these support cells to turn
into neurons in
the brain, and we found we could get them to do it. Something in the
environment in the
rodent brain is sufficient to get these cells to become neurons."
Id. n.13
(Emph. added).
We now have lab mice
with human grey matter, or humanly induced new grey matter, successfully
implanted in their cortexes (Hopefully no mice escape). This is yet another jewel, a gem (but
potentially a dark and secretive one).
Science is now passing a major hurdle, and that hurdle devolves upon the
"dormant" progenitor cell within the grey matter, the brain's most
conspicuous underachiever, which cell performed spectacularly for the McKnight
group as above, and which group did exhaustive work, to produce functioning
neurons for the cortex. As a caveat, the
donor tissue came from the temporal lobe grey matter of an epilepsy patient,
and that condition is known to give neurogenesis a
boost. "[T]he
dynamics of network remodeling in the mature CNS are dramatically altered in
the setting of injury and include modulation of neurogenesis
and . . . ." 14/
We're
coming to calcite now, #3 on the Moh's scale, and to
the crystalline caves. Injury boosts neurogenesis. Are
you surprised? Here it begins. The brain grows bigger, and changes structure
with physical exercise, according to varying results among the elderly and
athletes. Brains
increase with lithium and, quite surprisingly with a few chemical
antidepressants ie. Prozac
and Depakote.
On the lithium/brain MRS (Id. at
Psycheducation.org) you see regrowth around periphery
of the cerebral cortex and 'internally' along ventricle walls. One electromagnetic treatment device, the PAPIMI (basis of this website) remarkably increases, and
restores injured regions of the brain.
We know all this according to MRI and MRS imaging. Neurogenesis within the dentate gyrus, is increased by a
stimulating environment, as it is with injury, as revealed in lab mice. You the reader, may know of other instances
of neurogenesis to add to this list. Other neurogenesis
may be discovered in the time it takes this text to have reached you. Here's a rhetorical question; are not the
instances of naturally occuring or very common, and
not so common brain restoration here, the ideal subjects of study for efforts
by scientists to tap the brain's dynamics of neuronal network remodeling and
attenuate the brain's intrinsic mechanisms for self repair toward full
functionality? (Ref. generally, Id. n. 13, 14) I'm getting to us by this
time.
Doctors and scientists couldn't
be having an easy time of it. Doctors
are now unlearning "the 1/2 they learned wrong", when in medical
school. Next, there exists no unified
field of study which would involve all the specialties incl. ex. sports doctor,
gerontologist, neuropsychiatrist, stem cell
researcher, and last but not least physicist (the PAPIMI)
which come upon our subject, the subject of neurogenesis. Ex. a clinical psychiatrist, may not know
that the lithium they prescribe to their patients promotes neurogenesis,
and this is an extreme and microcosmic example of segregation of information,
so we can only imagine the larger segregations between and among the whole
specialties mentioned here. Lastly, new
needs and expectations might be thrust upon them with regularity. Need, expectation--cart and horse. Ex. technology creates needs, for instance
the MRI. What
happens when new needs outpace expectations?
Never before have
so many different specialties converged upon one single body organ, as
they do the brain, for its newfound plasticity.
What one thing do they all know about the brain, and expect of it? For argument, let's assume they are, each and all, guarding their own secrets until time is
ripe. And let's assume they are meting
out a pecking order among themselves and let's say the putative neural stem
cell takes priority. What do they all
want? And the answer should be just a
few words. They want to get inside
the brain. This is the answer, I
think. And why? The brain's environment is a hospitable one,
and there are many new challenges to be met there. These very words, iterated in the literature,
are no better put than this:
regeneration of neuronal networks as once believed. . . .
. . . .
. . . .
Furthermore, the mature CNS continues to express a variety of molecules
that are required
for the formation of neuronal networks during embryonic development
. . . . suggesting that the degree of potential network remodeling
in the mature CNS
may be more extensive than generally thought.
(Id. n.
14, article "Brain, Heal Thyself" 1999, authors at Neurology Dept. UCSF) (Emph. added)
They need us.
They need the clinically depressed, the growing and younger numbers
brain atrophied, all the diseases of aging, including the growing incidence of
Alzheimer's disease, the World-changing baby boomers for whom aging itself is a
disease, the neuroAIDS patients with five or possibly
more years to live with treatment, the walking injured, and even the idle.
How will they reach
us? This is a difficult question. My own treatment with PAPIMI
to the brain, came as a very fortunate fluke, a
serendipity. The FDA's footprint on the
ground is this: FDA-proven electromagnetic devices have a narrow approval to
treat (a) post-operative swelling & pain in superficial tissue, and (b)
bone fractures that hadn't healed in +4 months.
Note electromagnetics is not
approved to treat bone fractures at earliest onset, in spite of overwhelming
evidence it reduces inflammation and pain while stimulating growth and repair
almost immediately. Thus electromagnetics is consigned to a treatment of last
resort, and placed in hospital 'back rooms', and some burn wards. Good though, devices are ubiquitous in
orthopedic wards and clinics. Bones, no less.
But the PAPIMI hasn't joined them yet.
What can you do while waiting for
treatment to reach you? You can buy a small
electromagnetic device from the internet and use it. It's absolutely
surprising, what is out there, and prices are cheap. In some cases to use a device, you'll be a
"researcher" in a Phase 1 FDA trial.
And you'll be a researcher in truest sense, having to decide, ex.
whether or not to apply nanoseconds to your or others' bod(ies) from a pocketsized device
designed, in kind it’s said for NASA astronauts, or, alternatively whether you
can build a basic device yourself from schematics published free on the
internet but then, you could hurt yourself.
I myself, sit somewhere in the middle (of what?) with a Dr. Beck device
which he states he could have patented but didn't, which he tells others how to
make, and which was conceived from research suppressed (quoting Beck) at the
Albert Einstein School of Medicine which is the successful removal of AIDS
virus from the blood using electricity.
I recently bought Dr. Beck's electromagnetic device, which is one part
of his four part protocol to choose from.
Buy a device on the internet, and
use it. Moreover you make this your
emergency, First Aid medicine and you do this deliberately. 'There are tactics
and there is strategy' and make no mistake about it, there is war over the new Bioelectrics:
“Big Pharma Fears Electricity . . .” by Tim
Bolen
http://www.quackpotwatch.org/opinionpieces/big_pharma_fears_electricity.htm
You'll
make electromagnetics your medicine of first resort,
you'll support that market, let your doctors know it and tell your
friends. For First Aid, the nanosecond
device above, is the EM-Pulse; it's
battery operated, and no doubt very useful in isolated or extreme situations
but watch out, it up and down regulates your genes (See n. 9 Id., and EM-PROBE website).
It's a curiosity what they let onto the market, as much as is what they
withhold. Be a tactician and a
strategist too.
Follow the news on PAPIMI--it is in fact the king of the devices and we meditate
for its entry to the U.S. market.
Meditate? Yes!
You are welcome to join me in meditation for any few moments on Sunday
between hours of 1:30 – 2:00 p.m. PST (U.S. Pacific Standard Time), for the
entry of PAPIMI into the U.S. market. And “be careful what you wish for.” We want PAPIMI
for general medical use—you don’t want to have to be admitted to burn or
orthopedic ward for ‘nonhealing’ injuries, or go ‘around
the corner’ to get to it. If this
helps, then my neurogenesis, may be yours.
Arguably, if group meditation can lower the homicide rate in major
cities, and if military intelligence uses ‘remote viewing’ successfully in
espionage, then it’s not such a far stretch, for us to do this. Please send me your notes of encouragement if
you participate.
Take lithium! It's available over the counter as a health
supplement.
Seriously, go to the world's show
caves site www.i-s-c-a.com, and step down into nature's sealed rooms. There's enough calcite for everybody. As the new images of neurogenesis
settle in, you'll do well with some distraction now and those caves are
just the place. The Biblical story of
Genesis may rise to your attention and this won't feel comfortable, but don't
try to stop it. You can't stop it. Good and evil, bad tree, live forever
xenophobic. Nonesense? Be truthful.
But it's a telling tale, if our original state was known to be one of
perpetual renewal. And it's not only
brain cells which renew--women's eggs, her ooctyes
renew throughout adult reproductive life. 15/ These recent discoveries put us in a
different stance. Good and evil, this is
the wrench. Where do these thoughts take
you? And for me?
Of course a group of 150 year olds would construct a different moral code than
20 year olds would, or could. Where is
this headed? Possibly it's a mountain mineral water trail, possibly older than
we'd imagined. (Begley
S. “Beyond Stones & Bones” Newsweek 3/19/2007 map at p. 57). If you throw out cultural biases it could be
a very interesting story.
1/
Colucci-D'Amato L. et al., "The end of the
central dogma of neurobiology: stem cells & neurogenesis
in adult CNS", Neurol. Sci. [Neurological Sciences (Italian)]
2006 Sep:27
(4):266-70
2/ Gross, CG, "Neurogenesis
in the adult brain: death of a dogma" Nat. Rev. Neurosci.
2000 1:67-73
3/
For description of hyppocampus
including dentate gyrus, see: "The Neurogenesis
Story" at Dr. Jim Phelps' educational website,
http://www.psycheducation.org/mechanism/images/NeurogenesisDetail
4/
Eriksson P. et al., "Neurogenesis in the
adult human hyppocampus", Nature Medicine 1998
Nov; 4(11):1313-17 (The brains were from Sahlgrenska
U. Hospital in
Sweden and the work took place at Salk
Institute in San Diego--this was a collaboration which included Drs. Eriksson
and Gage in their two respective countries.)
5/ Johnson G., "Lots of Action in
the Memory Game" Time Magazine Jun 12 2000
6/ Moore GJ et
al., "Lithium increases N-acetyl-aspartate in
the human brain: in vivo evidence in support of bcl-2's neurotrophic
effects?"
Biol. Psychiatry 2000 Jul 1;48(1):1-8 (Collaboration Wayne State U., Detroit, Mich. and
Dr. HK Manji of NIMH)
7/ Moore G.L.
et al., "Lithium-induced increase in human grey matter" Lancet
2000; 356: 1, 241-1, 242
8/
U.S. Patent No. 5,556,418 issued 9/17/96 "Method and apparatus for
pulsed magnetic induction. PCT Patent 1993. OBI
Patent
1001784 (Inventor Dr. P. Pappas)
9/ Schoenbach
K. et al., "Zap: Extreme voltage could be a surprisingly delicate tool in
the fight against cancer" IEEE Spectrum Online
Aug 2006 ( http://www.spectrum.ieee.org/aug06/4257
)
10/ (Research
Highlights) "CAM for the Military, Grant Activities" NFAM Year's End Newsletter 2004, online at
http://www.nfam.org/2004yearendnewsletter_military.html
11/ Wright LS
et al., "Human progenitor cells isolated from the developing cortex
undergo decreased neurogenesis and eventual
senescence
following expansion in vitro" Experimental Cell Research Epub 2006 Apr 24 2(11):2107-20
12/ Ostenfeld T. et al., "Requirement for neurogenesis to proceed through the division of neuronal
progenitors following
differentiation
of epidermal growth factor and fibroblast growth factor-2-responsive human
neural stem cells", Stem Cells 2004;
22:798-811 (Copyright © 2006, Stem Cells
Online by AlphaMed Press)
(Access this article online at
http://stemcells.alphamedpress.org/cgi/content/full/22/5/798
)
13/ Walton N.
et al., "Derivation and large-scale expansion of multipotent
astroglial neural progenitors from adult human
brain"
Development 2006 133(18):3671-3681
14/
Lowenstein D. et al., "Brain, Heal Thyself", Science 1999 Feb
19; 283:1126-27
15/ Susan Sawicki’s website http://www.as-a-woman-eats.com
Susan
Sawicki e-mail: susan.sawicki@yahoo.com
Alternate e-mail: sawicki_savickas@hotmail.com
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